Madeleine K Wyburd

I am a Danish Data Science Academy (DDSA) postdoctoral fellow, working in the recently established LNN@UCPH at the University of Copenhagen. I am an associate member of Oxford Machine Learning NeuroImaging Lab (OMNI) at the University of Oxford, with Prof Ana Namburete.

Email  /  Google Scholar  /  Github

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Research

In my current role, I am developing deep learning methods to monitor fetal and infant brain development. I am particularly interested in the early detection of cerebral palsy from neuroimaging. During my DPhil, I developed a fully automated pipeline to characterise the healthy cortical development. I am now looking at at-risk pregnancies to see how their development varies.

Selected Publications










Normative growth trajectories of fetal brain regions validated by satisfactory maturation of neurodevelopmental domains at 2 years of age
Madeleine K Wyburd ... Intergrowth Consortium, Ana IL Namburete
Nature Communications, 2026

Paper / Code

Normative growth trajectories of 28 fetal brain phenotypes derived from 4205 3D ultrasound scans collected across 7 international sites. The low variance between sites reinforces the principle that the brain develops similarly when environmental constraints are minimal.

Deep learning in fetal, infant, and toddler neuroimaging research
Madeleine K Wyburd , Jenna Chin... Lilla Zollei and Catalina Camacho
Developmental Cognitive Neuroscience, 2025

Paper

Cross-Modality Comparison of Fetal Brain Phenotypes: Insights From Short-Interval Second-Trimester MRI and Ultrasound Imaging
Madeleine K Wyburd , Nicola Dinsdale,... Ana IL Namburete
Human Brain Mapping, 2025

Paper / Code

Comparing ultrasound and MRI fetal brain features from same day scanning.

Anatomically Plausible Segmentations: Explicitly Preserving Topology Through Prior Deformations.”s
Madeleine K Wyburd , Nicola Dinsdale, Ana IL Namburete, Mark Jenkinson
Medical Image Analysis, 2024

Project Page / Paper / Code

Extension from the 2021 MICCAI paper.

Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years
Ana IL Namburete, Madeleine K Wyburd ... Intergrowth Consortium
Nature, 2023

Paper

TEDS-Net: Enforcing Diffeomorphisms in Spatial Transformers to Guarantee Topology Preservation in Segmentations
Madeleine K Wyburd , Nicola Dinsdale, Ana IL Namburete, Mark Jenkinson
MICCAI, 2021 [Early Acceptance]- Conference Proceedings + Presentation

Project Page / Paper / Code

Novel segmentation method guaranteeing accurate topology.

Automated grading of fetal cortical development using deep-learning algorithms: A preliminary 3D ultrasound study in healthy fetuses
Madeleine K Wyburd , Linde Hesse,Moska Aliasi, Felipe Moser, Monique C. Haak, Aris Papageorghiou, the INTEGROWTH-21st Consortium, Ana IL Namburete
ISUOG, 2021 - Oral Presentation

More Information Coming Soon

Deep learning-based assessment of second trimester cortical plate development in 3D ultrasound
Madeleine K Wyburd , Aris Papageorghiou,Mark Jenkinson Ana IL Namburete
ISUOG, 2021 - Oral Presentation

More Information Coming Soon

Using Deep Learning to Segment the Developing Cortical Plate from 3D Fetal Ultrasound.
Madeleine K Wyburd , Mark Jenkinson Ana IL Namburete
RSNA, 2020 - Poster Presentation
Cortical Plate Segmentation using CNNs in 3D Fetal Ultrasound
Madeleine K Wyburd, Ana IL Namburete, Mark Jenkinson
MIUA, 2020 - Conference Proceedings + Presentation

Paper / Presentation

Initial cortical plate segmentation methods


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